STUDIES ON T H E MECHANISM OF IMMUNITY IN TUBERCULOSIS Tm~ FATE OF TUBERCLE BACILLI INGESTED BY MONONUCLEAR PHAGOCYTES DERIVED FROM NORMAL AND IMMUNIZED ANIMALS BY MAX B. LURIE, M.D. WITH THE COLLABORATION OF PETER ZAPPASODI
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Studies on the Mechanism of Immunity in Tuberculosis
1. Tuberculous and vaccinated rabbits and guinea pigs mobilize mononuclear phagocytes at the site of a non-specific inflammation with greater rapidity than do normal animals, just as they respond to tubercle bacilli. 2. The succession of cells that characterizes inflammation in general is accelerated in allergic rabbits and guinea pigs in response to non specific irritants. 3. The pH at the sit...
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The investigations of Rich (1) and his associates have cast profound doubt on the r61e of allergy in immunity to tuberculosis. Their studies intimate that both the fixation of tubercle bacilli at the site of reinfection and the inhibition of their growth may take place in the absence of exaggerated inflammation. Many studies (2) since then have indicated that there is no strict parallel between...
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Earlier studies (1, 2) on the tubercle bacillus-monocyte relationship were directed towards an understanding first of procedural problems, a solution to which was essential if the "natural history" (in a tissue culture type of environment) of the fate of parasitized monocytes was to be recorded. Preliminary trypsinization of rabbit monocytes and employment of 40 per cent rabbit serum in Tyrode'...
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